Xenotransplantation

zɛn.oʊˌtræns.plænˈteɪ.ʃən or ˌziː.nəʊˌtræns.plɑːnˈteɪ.ʃən

noun

The surgical transfer of cells, tissues, or especially whole organs from one species to another.

Xenotransplantation

zɛn.oʊˌtræns.plænˈteɪ.ʃən or ˌziː.nəʊˌtræns.plɑːnˈteɪ.ʃən

noun

The surgical transfer of cells, tissues, or especially whole organs from one species to another.

Revolutionizing
Transplant Medicine

Xenotransplantation offers a breakthrough solution to the global organ shortage. By using advanced gene-edited porcine cells, we can transplant life-saving tissues from pigs to human patients – providing a sustainable, accessible, and affordable alternative to traditional organ donation.

However, two primary challenges have prevented xenotransplantation from becoming a reality:

Risk of cross-species viral transmission

Porcine species harbor endogenous retroviruses that pose risks to human recipients

Immune-mediated organ rejection:

The human immune system may recognize porcine organs as foreign, leading to rapid rejection

With recent advancements in gene-editing technology, Prana XT is pioneering solutions to overcome these challenges in making xenotransplantation a reality.

The Journey from Cell to Transplant

01. Stable Genetic Modifications

Porcines are engineered to prevent immune rejection by deleting problematic genes and incorporating human genes to improve compatibility.

Porcines are raised in sterile, highly monitored facilities to eliminate the risk of infections.

Once matured, these animals provide transplantable kidneys, hearts, and other tissues that can save human lives.

History of Xenotransplantation

Circa 1000 CE

Indian folklore and mythology contain references to divine limb replacements and miraculous healing, like Ganesha’s head.

1971

The first successful kidney transplant in India was performed in 1971 at the Christian Medical College, Vellore, paving the way for future transplant research.

1984

The infamous Baby Fae case, where a baboon heart is transplanted into an infant, momentarily sparking hope. However, she survives only 21 days due to organ rejection.

2010

CRISPR gene-editing technology emerges, allowing scientists to precisely alter animal genes to make them more human-compatible.

2022

The first successful transplant of a genetically modified porcine heart into a human patient takes place, marking a breakthrough in xenotransplantation.

2025 & beyond

Companies like Prana XT are working to bring gene-edited porcine organs to patients in India, making life-saving transplants more accessible than ever.

History of Xenotransplantation

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Circa 1000 CE

Indian folklore and mythology contain references to divine limb replacements and miraculous healing. (E.g. Ganesha's elephant head?)

2019

2023

Image description

1971

The first successful kidney transplant in India was performed in 1971 at the Christian Medical College, Vellore, paving the way for future transplant research.

Image description

1984

The infamous Baby Fae case, where a baboon heart is transplanted into an infant, momentarily sparks hope. However, she survives only 21 days due to organ rejection.

2023

2023

Image description

2010

CRISPR gene-editing technology emerges, allowing scientists to precisely alter animal genes to make them more human-compatible.

Image description

2022

The first successful transplant of a genetically modified porcine heart into a human patient takes place, marking a breakthrough in xenotransplantation.

2022

2025 & beyond

Image description

2025 & beyond

Companies like Prana XT are working to bring gene-edited porcine organs to patients in India, making life-saving transplants more accessible than ever.